nk-1 antagonist 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12233	NK-1 Antagonist 1	Rolapitant intermediate	Others
	NK-1 Antagonist 1 is a NK-1 receptor antagonist.		Others
T8235	L-732138		Neurokinin receptor
	L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)		Neurokinin receptor
T69140	Burapitant	SSR 240600	Neurokinin receptor
	Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.		Neurokinin receptor
T7939	Fingolimod	FTY-720A,FTY-720	S1P Receptor , PAK , LPL Receptor
	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).		S1P Receptor , PAK , LPL Receptor
T25615	Lanepitant	LY303870,LY-303870,LY 303870	Others
	Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine.		Others
T12000	MEN11467		Neurokinin receptor
	MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.		Neurokinin receptor
T38144	Elinzanetant		Neurokinin receptor
	Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.		Neurokinin receptor
T2539	Fingolimod hydrochloride	Fingolimod (FTY720) HCl,FTY720	TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
	Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).		TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
T28706	SCH 206272	SCH206272,SCH-206272
	SCH 206272 is a potent, orally active antagonist of tachykinin NK(1), NK(2), and NK(3) receptor.
T70295	MDL-105212A HCl
	MDL-105212A HCl is a nonpeptide NK-1 and NK-2 receptor antagonist.
TQ0087	NKP608		Neurokinin receptor
	NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.		Neurokinin receptor
T4533	Serlopitant
	Serlopitant is a selective antagonist of Neurokinin-1 (NK-1) receptor.
T76431	GR 83074
	GR 83074 is a potent and selective antagonist of the NK-2 (Neurokinin Receptor), demonstrating a selectivity factor of 340-fold over NK-1, with a pK B value of 8.23. It does not act as an antagonist for NK-3, affirming i...
T76405	[D-Trp2,7,9] Substance P
	[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist that exhibits inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].
T29185	YM44781	YM 44781,YM-44781
	YM44781 is a non-peptide tachykinin receptor antagonist. YM44781 exhibits high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively.
T29186	YM49598	YM-49598,YM 49598
	YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced ...
T75880	GR 94800 TFA
	GR 94800 TFA is a potent, selective antagonist of the NK 2 receptor peptide, demonstrating pK B values of 9.6 for NK 2, 6.4 for NK 1, and 6.0 for NK 3 receptors, respectively [1] [2].
T16406	Orvepitant maleate	GW823296 maleate	Neurokinin receptor
	Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chro...		Neurokinin receptor
T76446	(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P
	(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK 1 receptor antagonist [1] .
T72820	(R)-Casopitant	(R)-GW679769
	(R)-Casopitant ((R)-GW679769), an isomer of Casopitant, functions as an NK(1)-receptor antagonist. It has applications in the study of chemotherapy-induced nausea and vomiting [1] [2].